Center for Excellence in Diabetes and Obesity Research
This application is to support Phase III of the COBRE-supported Diabetes and Obesity Center at the University of Louisville. The Center was established in 2008, with the central objective of supporting molecular, cellular, experimental, translational, and clinical investigations into the cardiovascular causes and consequences of diabetes and obesity. During Phase I and II, the Center […]
Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation
We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research and Innovation at the University of Kentucky (UK). CPRI will serve as a comprehensive multidisciplinary center focused on translational chemical biology [the nexus of chemical biology (the application of chemical biology principles to develop validated probe/models to advance our understanding of […]
Functional Microbiomics, Inflammation and Pathogenicity
In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances which have shaped our understanding of microbes as components of complex, polymicrobial, interactive communities. This microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances […]
Center for Cancer Immunology and Immunotherapy
The objective of this program is to establish a thematic multidisciplinary research center of excellence at the University of Louisville (UofL) named the Center for Cancer Immunology and Immunotherapy (CCII). The mission of the CCII is to conduct outstanding biomedical research that works towards harnessing the power of the immune system to eradicate cancer. There […]
University of Kentucky Center for Cancer and Metabolism
Cancer cell survival traits such as suppressed apoptosis, rapid cell cycling and proliferation, and the ability to metastasize from a primary location require extensive metabolic reprogramming of the tumor microenvironment. Intriguing new insights into the novel role of metabolic dysregulation in tumorigenesis and metastasis increasingly draw attention to currently understudied areas of cancer research: the […]
Hepatobiology and Toxicology COBRE
The University of Louisville (UofL) Hepatobiology and Toxicology (H&T) COBRE is a unique thematic center focused on liver research. The UofL H&T COBRE concentrates on the mechanisms and therapeutic strategies for multiple forms of liver disease/injury, including Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis—the most common liver disease in the US/worldwide, and is highly linked to the […]
Bioengineering Center for Regeneration and Formation of Tissues
This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center’s […]
COBRE:Eukaryotic Pathogens Innovation Center
Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, sleeping sickness, Chagas disease, and meningitis. The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs) and/or are also […]
COBRE in Stroke Recovery
The overall goal of this Phase II COBRE is to enable outstanding multidisciplinary collaborative research in recovery from stroke. Stroke recovery research is especially important to South Carolina, because a disproportionate rate of stroke incidence statewide results in undue economic, social and personal burdens from post-stroke disability. Our organizing concept is that increased understanding of […]
COBRE in Digestive & Liver Disease
The overall goal of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enable outstanding multidisciplinary collaborative research in digestive and liver diseases at the Medical University of South Carolina. These diseases are of importance to the state of South Carolina because of the tremendous, disproportionate burden they have […]