High-Content, High-Throughput Multi-Mode Imaging System
This proposal requests funds to acquire a BIOTEK Cytation 5 multimode (imaging) reader with BioSpa automated incubator and MultiFlo liquid handler for the Medical University of South Carolina to support the drug discovery effort of NIH-funded investigators. The equipment will be housed in the Department of Drug Discovery & Biomedical Sciences (DDBS) and will be […]
Kv7 channels and heavy alcohol drinking
Excessive alcohol (ethanol) consumption is a hallmark characteristic of individuals with alcohol use disorder (AUD) and a risk factor for developing alcohol dependence. Mood and anxiety disorders that are often comorbid with AUD can hinder psychosocial treatment interventions and increase the risk of relapse. While current FDA approved medications are not effective in the general […]
Neural mechanisms underlying integration of taste and smell
Although interactions between the senses of smell and taste are a key factor for guiding food choices, the neural mechanisms underlying the multisensory integration of odors and tastes remain largely unknown. A more thorough understanding of these neurobiological processes will provide better insight into diseases characterized by unhealthy food choices, such as obesity or diabetes. […]
Surveillance and identification of variants of concern within circulating SARS-CoV-2 across Kentucky
The emergence and circulation of SARS-CoV-2, the virus that causes COVID-19 disease, has led to >125 million infections and more than 2.5 million deaths worldwide in just over 1 year. Global sequencing efforts have identified several viral variants of concern (VOC) and interest (VOI) that result in increased transmission rates and/or increased mortality for those […]
Center for the Biologic Basis of Oral/Systemic Diseases
Systemic Diseases (CBBO/SD)” is to continue the sustainability of a nationally competitive transdisciplinary research center focusing on oral healt sciences and systemic diseases within the University of Kentucky. This proposal builds upon the Phase l/ll funding for developing the research infrastructure in the College of Dentistry and supporting junior investigators to develop competitive research programs […]
Evaluation of endocrine pancreas development, beta cell mass expansion, and regeneration in glis3 mutant zebrafish
The endocrine pancreas is responsible for the production of several hormones, including insulin, important in the regulation of carbohydrate metabolism and glucose homeostasis. Both the development of the endocrine pancreas and its proper function within the context of the mature organ rely on networks of transcription factors that are not yet well understood. Among these, […]
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR Spectrometer
This proposal requests funds for the purchase of a state-of-the-art Bruker AVANCE NEO 600 MHz high-performance digital NMR spectrometer, which will be housed in the University of Kentucky (UK) PharmNMR Center located in the College of Pharmacy. The requested spectrometer offers capabilities that exceed by far those of the existing NMR instruments currently accessible to […]
Insulin Degrading Enzyme: Physiological Function and its Spatial and Activity Modulation
Insulin-degrading enzyme (IDE, insulysin) is a primarily cytosolic peptidase shown to be important in the catabolism of insulin, the amyloid-beta peptide, and likely other signaling and intracellular peptides. Its cellular physiology is therefore of considerable interest in the treatment of disorders such as diabetes and Alzheimer’s disease. However, the site of IDE action on these […]
SC COBRE for Translational Research Improving Musculoskeletal Health
The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to enhance and expand the Biomedical Research capacity at Clemson University to promote outstanding multidisciplinary, collaborative, and translational research in bone and joint diseases. A new scientific concept for translational research, i.e. Virtual Human Trials, is to be implemented […]
Center of Research on Obesity and Cardiovascular Disease
Phase III of the Center for Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases (COCVD) will further develop and expand upon obesity as an underlying risk factor for the development of cardiovascular diseases, type 2 diabetes, cancer, and neurodegenerative diseases. Each of these diseases are rampant in Kentucky, and obesity has been identified as […]