Translational Research to Prevent and Control Global Infectious Diseases
Overall Component Despite striking advances in the 20th and early 21st century, infectious diseases are dynamic, ever-evolving global threats that cause significant morbidity and mortality in all populations worldwide. Within a single year, Zika has emerged, massive outbreaks of cholera have occurred, and antimicrobial resistance has become a critical international concern. This landscape demands new […]
Vermont Immunobiology And Infectious Diseases Center
The Vermont Center for Immunology and Infectious Diseases (VCIID) COBRE is about to enter its 10th year. During this period, VCIID has grown from 9 founding faculty to 25 and produced 416 publications and $92 million in grant support and 14 patents. Twelve junior faculty were supported with COBRE funding during Phases I and II […]
iTarget: Institute for Biomolecular Targeting
Investments in biomedical research have paid large dividends in the form of groundbreaking treatments for a host of diseases. Efforts to accelerate such benefits often assume there is a linear progression that begins with an understanding of basic biological principles, and then advances to therapeutic development, evaluation, and ultimately clinical application. As a result, many […]
Center of Integrated Biomedical and Bioengineering Research
Untangling the complex interactions of genes, environment, behavior, and human diseases requires multidisciplinary perspectives and state-of-the-art technology. Recognizing this need, the University of New Hampshire (UNH) has implemented a strategy to increase the number of faculty conducting research in basic biomedical science, bioengineering, and behavioral sciences. These initiatives have been accompanied by sustained investments in […]
Center for Molecular Epidemiology
Establishing the Center for Molecular Epidemiology, Center for Biomedical Research Excellence (COBRE) has transformed research in the field of molecular epidemiology at Dartmouth. As the only Center for Molecular Epidemiology in northern New England, and one of the only COBRE programs nationally with this focus, we have successfully recruited and mentored early career investigators who […]
The Delaware Comprehensive Sickle Cell Research Center
The Delaware Comprehensive Sickle Cell Research Program (a consortium between A.I. DuPont Hospital for Children and Delaware State Univ.) will build upon strengths in Biomedical Research, clinical care and recent recruitments to create a sustainable infrastructure supportive of target investigators and state-of-the art research. Three Target Investigator proposals and two Pilots comprise a well balanced […]
Delaware Center for Musculoskeletal Research
The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, […]
An experimental evaluation of e-cigarettes in young adults: Reinforcement enhancement and devaluation by nicotine
One concern about e-cigarettes is their abuse potential; however, we know of no systematic study of this in a young adult population. Abuse-liability assessments traditionally include the analysis of positive subjective effects and of self-administration, but these may fall short of accurately characterizing the abuse potential of tobacco products because recent preclinical studies indicate some […]
COBRE Center on Opioids and Overdose
We propose to build and sustain the Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use disorder and a need for more effective interventions […]
COBRE for Skeletal Health & Repair
The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years ago, seven full project investigators have received R01 or […]