Molecular Design of Advanced Biomaterials
We propose to build on the success of COBRE phase I and phase II awards to establish four research cores that will provide the infrastructure to take our Center to the next level. In addition, COBRE III will provide a mechanism for pilot research projects to continue to develop vibrant teams of investigators in biomaterials […]
Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in Delaware
In this project, our team seeks to develop and evaluate a unique predictive modeling approach that can be applied to the spread of SARS-CoV-2 and subsequently adapted to address other emergent infectious diseases. Robust and accurate predictive models are needed to allow healthcare and public health experts to devise and evaluate interventions for controlling viral […]
Delaware INBRE
Overall The overall mission of the Delaware INBRE (DE-INBRE) program is to further grow a collaborative, multidisciplinary biomedical research network in Delaware that creates and supports sustainable collaborative research programs that address strategic health issues for the State, embraces diversity, and produces a positive impact on Delaware’s workforce and economy. The DE-INBRE network consists of […]
Center for Central Nervous System Function
Purposeful human behavior requires attention, decisions and construction and production of abstract sequences, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. In a general and even a specific sense, attention, decision making and production of abstract sequences are key components of human mental activities. […]
RI- Advance Clinical and Translational Research (CTR)
The universities, hospitals, government agencies and community organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Rhode Island’s small size, population demographics, and organizational structure are assets and present opportunities to implement and test transformative clinical and translational research. The health care delivery environment within […]
COBRE Center for Antimicrobial Resistance and Therapeutic Discovery
Overall Resistance to antimicrobial therapies is a national and international crisis that threatens clinical practice from fundamental primary care to the most advanced medical interventions such as cancer chemotherapy and organ transplantation. Much of what we take for granted in clinical medicine could become too risky as microorganisms have become increasingly resistant to our newest […]
Renewal of Delaware Center for Neuroscience Research
The Delaware Center for Neuroscience Research, established in 2012 with a phase I COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD) that uniquely brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and […]
Comparative Biology of Tissue Repair, Regeneration and Aging
Regeneration of damaged and lost tissues is limited in humans and other mammals. However, robust regeneration is the norm for numerous diverse invertebrates and lower vertebrates. COBRE Phase I, Comparative Biology of Tissue Repair, Regeneration and Aging, played a central role in establishing and growing the Kathryn W. Davis Center for Regenerative Biology and Medicine […]
Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities
Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care […]
Mesenchymal and Neural Regulation of Metabolic Networks
Whole body metabolism is regulated by the integration of multiple organ systems, including adipose tissue, the skeleton, and bone marrow. Imbalance in the regulation of these tissues leads to chronic disorders such as obesity and osteoporosis. Adipocytes and osteoprogenitor cells share a common mesenchymal precursor, and link these two highly prevalent diseases. Mesenchymal progenitors are […]