COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health
This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness […]
COBRE Center for Neuromodulation
The COBRE Center for Neuromodulation (CCN) will be centered at Butler Hospital, a freestanding psychiatric and neuropsychiatric hospital affiliated with the Alpert Medical School at Brown University. This COBRE will create key infrastructure and support a core group of interdisciplinary investigators to build a self-sustaining center of excellence in clinical-translational brain research. Its overall goal […]
COBRE for Reproductive Health
Pregnancy is a critically important time in a woman’s life and it is recognized as a window into women’s future health. Although the overwhelming majority of patients have a healthy outcome, pregnancy complications have been on the rise globally. New and emerging data strongly suggest significant maternal health consequences after pregnancies complicated by preeclampsia, diabetes […]
CardioPulmonary Vascular Biology COBRE
The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and cardiovascular systems. This vision will be accomplished through research performed by a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases. […]
COBRE for Perinatal Biology
The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the […]
COBRE: Center for Computational Biology of Human Disease
We propose to establish and build the COBRE Center for the Computational Biology of Human Disease at Brown University and affiliated hospitals. The motivation for this effort lies in the joint promise that personalized genomic medicine and novel analyses of Big Data are key elements in the identification and treatment of human disease. Sequencing a […]
Center for Addiction and Disease Risk Exacerbation
Substance use (SU) negatively affects the risk, management, progression, and outcomes of chronic disease and contributes to socio-economic and racial/ethnic disparities. Prevalence rates of medical conditions among patients with versus those without substance abuse disorders (SUDs) support this thesis. Furthermore, risks are exacerbated among those at risk for or who already have chronic medical conditions, […]
Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function
Treatment of chronic pain continues to rely on old drugs such as gabapentinoids, reuptake blockers and opioids, all of which have severe side effects that diminish quality of life. Tolerance develops to opioids with chronic use, and an increase in opioid prescriptions has contributed to the growing opioid addiction epidemic. There is an urgent need […]