Oklahoma COBRE in Structural Biology
Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase I funding. The OCSB supports faculty research projects and three core facilities on the OU-Norman and OU Health Sciences […]
Oklahoma Center for Microbial Pathogenesis and Immunity
The goal of this Phase-1 COBRE program is to develop and enhance the research infrastructure, mentoring, and collaborative environment to support five Junior Investigators in the multi-disciplinary fields of microbial pathogenesis and immunity. To achieve this goal, The Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) COBRE will be established and fostered as a center […]
Mentoring Translational Cancer Research in Oklahoma
The overall objectives of the proposal are to improve the quality and quantity of cancer research and increase NIH funding at the University of Oklahoma Health Sciences Center (OUHSC), Oklahoma through the mentoring of promising junior Target investigators (Target investigators) and to develop support for the infrastructure for cancer research. Building on the success of […]
The Center for Neuroscience-based Mental Health Assessment and Prediction
Mood and anxiety disorders will account for approximately $16 x 109 lost productivity or 25% of global GDP over the next 20 years. Eating disorders are among the deadliest psychiatric diseases and Anorexia Nervosa is two to three times more deadly than schizophrenia, bipolar and major depressive disorder. The Center for Neuroscience-based Mental Health Assessment […]
Center for Visual and Cognitive Neuroscience
The NDSU COBRE Center for Visual and Cognitive Neuroscience (CVCN) has made significant progress toward fulfilling its Specific Aims in Phases I and II. We enhanced the biomedical research infrastructure by creating and maintaining six multiuser Scientific/Technical Core facilities. We expanded research capability in visual and cognitive neuroscience by recruiting six additional faculty into newly […]
Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical Research
The Mary L. Vanier Biomolecular NMR Facility at Kansas State University, which has served more than 30 separate NIH-funded research projects and several other life sciences research groups (Total 45), requests partial funding to replace an obsolete Varian 500 MHz NMR system (originally purchased in 1993) with a newer console and a 5 mm cryogenic-probe. […]
Center for Excellence In-Host Pathogen Interactions
The objective of this grant application is to establish a Center of Biomedical Excellence in Host- Pathogen interactions that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the mechanisms that underline the host respose to various infectious agents. We have proposed five new independent, but […]
Indigenous Trauma & Resilience Research Center
Indigenous populations experience significant trauma-related health disparities, including addiction, post- traumatic stress disorder, chronic diseases, infant mortality, and suicide. Many of these disparities are worse for American Indians (AIs) in the Dakotas. AI communities also contend with historical and intergenerational trauma from decades of traumatic losses and forced assimilation. Hence, we will establish the Indigenous […]
Center for Biobehavioral Mechanisms of Eating Behavior
We propose to establish a Center for Bio-behavioral Mechanisms of Eating Behavior (CBM-EB) at Sanford Research, Fargo along with the University of North Dakota School of Medicine and North Dakota State University (NDSU). The proposed CBM-EB will initially consist of five thematically related research projects focusing on mechanisms related to eating disorders and maladaptive eating […]
Mechanisms of Liver Injury and Diseases
Liver diseases including alcohol- and drug-induced liver injury, fatty liver disease, viral hepatitis, and liver cancer affects millions of people in he US. For the past 9 years the COBRE supported the recruitment of 15 junior faculty engaged in liver research and assisted in the development of highly successful core laboratories at the University of […]