Center of Biomedical Research Excellence, Epigenomics of Development and Disease
The goal of this COBRE II application is to expand and enhance research into epigenetic mechanisms underlying development and disease at the University of North Dakota by providing ongoing support to the Epigenetics Working Group (EWG). In COBRE I the EWG made significant progress towards development of an epigenetics/epigenomics program through support of individual projects; […]
Expanding Excellence in Developmental Biology in Oklahoma
Our overall goal is to strengthen our Developmental Biology COBRE by mentoring five newly-recruited investigators, each studying important questions in Developmental Biology with translational implications. We will build upon our success in Phase I when our COBRE Investigators made important discoveries resulting in 53 published papers (many in high-impact journals), 91 presentations at invited seminars […]
Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer
Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early […]
Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer
(Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short […]
Molecular Analysis of Disease Pathways
This proposal requests support to continue the development of the Center for Biomedical Research Excellence for Molecular Analysis of Disease Pathways (CMADP), which was established in 2012. The scientific theme of the CMADP is the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease. The Center […]
Chemical Biology of Infectious Disease
“Chemical biology is the focus of our efforts because it entails the discovery of chemical entities able to modulate pathways related to infectious processes. Such work can lead to an increase in biological understanding and the identification of novel targets for chemical intervention. Appropriate validation of such targets in advanced model systems, including animals, along […]
Cognitive and Neurobiological Approaches to Plasticity Center
This COBRE application will form a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (C-NAP). Four primary research projects bridge areas of excellence in the Cognitive and Behavioral Neuroscience programs at Kansas State University (KSU) and the Human Factors program at Wichita State University (WSU). The projects examine cognitive/neural plasticity across the […]
Center on Emerging and Zoonotic Infectious Diseases
This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Sciences and Veterinary Medicine. The projects examine virulence factors and host-pathogen interactions of various pathogens, […]
The Kansas Institute for Precision Medicine
The overall objective of the “Kansas Institute for Precision Medicine” (KIPM) COBRE at the University of Kansas Medical Center (KUMC) is to advance the customization of healthcare through promoting innovative scientific discoveries. The KIPM COBRE will provide support to advance the mission of KUMC through innovative mentoring and training programs with a precision medicine theme. […]
CIRCA, the Center for Integrative Research on Childhood Adversity
The proposed Center for Biomedical Research Excellence (CoBRE) will establish the Children’s Health Equity Solutions Center (CHESC). The long-term goal of the CHESC is to eliminate unjust differences in children’s health by race, ethnicity and socioeconomic status through effective translational science. The immediate goal of the CHESC is to build Oklahoma State University-Tulsa’s research environment […]