Oklahoma Shared Clinical and Translational Resources
An Oklahoma born in 2010 has the fifth lowest life-expectancy in the US and American Indians have the shortest, 7.3 years less than the US average. Cancer, diabetes, cardiovascular disease, arthritis, and autoimmunity are leading causes of disability and early mortality, serving as sources of major health disparities in Oklahoma and other IDeA-states. Along with […]
Mentoring Diabetes Research in Oklahoma
Oklahoma is one of the states in the US with the highest prevalence of diabetes, with 10% of the population affected. Diabetes is particularly prevalent among Native American communities, where it affects up to 40% of older individuals in some tribes. Thus, diabetes and its complications constitute a major threat to the working- age and […]
Oklahoma Center for Respiratory and Infectious Diseases
This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from […]
4.7T MRI for Translational Research Animal Facility
We are proposing to obtain a Bruker Biospin Advance Neo 47/40 USR pre-clinical MR imaging system with Paravision 360 software, including a 4.7T (Tesla) 40 cm magnet, gradient and shim coils (main and upgraded one for rodents), gradient/shim cooling, RF amplifiers, shim amplifier, Faraday cage, several RF volume and planar surface coils. For the proposed […]
Molecular Regulation of Cell Development and Differentiation Phase III COBRE
Funds are requested to renew a Center of Biomedical Research Excellence (COBRE) at the University of Kansas Medical Center (KUMC) as a Phase III, five year award. This COBRE has a research focus on the regulation of cell development and differentiation, which may provide new, therapeutic insights into a host of developmental abnormalities and diseases. […]
National IDeA Symposium of Biomecical Research Excellence
The Institutional Development Award (IDeA) Program within the National Institute of General Medical Sciences (NIGMS) promotes the development, coordination and sharing of research resources that increase the competitiveness of investigators in 23 IDeA-eligible states and Puerto Rico. The IDeA Program includes the Centers of Biomedical Research Excellence (COBRE), the IDeA Networks of Biomedical Research Excellence […]
Upgrade to 9.4T Animal MRI Scanner: Midwest Regional Resource
This proposal requests support for new animal MRI scanner electronics system that will replace an obsolete system and provide dramatically improved capabilities. Once installed, this state-of-the-art system will support research from NIH-funded investigators representing four IDeA State institutions in the Midwest: University of Kansas Medical Center, University of Kansas-Lawrence, Kansas State University, and Pittsburg State […]
Impact of Phosphaturia on Renal Osteopontin Production and PKD Progression
Autosomal dominant polycystic kidney disease (PKD) is characterized by the accumulation of numerous renal cysts leading to a progressive decline in kidney function, and frequently culminates in end-stage renal disease (ESRD). Aberrant tubular epithelial cell proliferation, macrophage infiltration, and tubulointerstitial fibrosis are important contributors to PKD progression; however, factors promoting these events remain undetermined. Systemic […]