Translational Research to Prevent and Control Global Infectious Diseases
Overall Component Despite striking advances in the 20th and early 21st century, infectious diseases are dynamic, ever-evolving global threats that cause significant morbidity and mortality in all populations worldwide. Within a single year, Zika has emerged, massive outbreaks of cholera have occurred, and antimicrobial resistance has become a critical international concern. This landscape demands new […]
Vermont Immunobiology And Infectious Diseases Center
The Vermont Center for Immunology and Infectious Diseases (VCIID) COBRE is about to enter its 10th year. During this period, VCIID has grown from 9 founding faculty to 25 and produced 416 publications and $92 million in grant support and 14 patents. Twelve junior faculty were supported with COBRE funding during Phases I and II […]
iTarget: Institute for Biomolecular Targeting
Investments in biomedical research have paid large dividends in the form of groundbreaking treatments for a host of diseases. Efforts to accelerate such benefits often assume there is a linear progression that begins with an understanding of basic biological principles, and then advances to therapeutic development, evaluation, and ultimately clinical application. As a result, many […]
Center of Integrated Biomedical and Bioengineering Research
Untangling the complex interactions of genes, environment, behavior, and human diseases requires multidisciplinary perspectives and state-of-the-art technology. Recognizing this need, the University of New Hampshire (UNH) has implemented a strategy to increase the number of faculty conducting research in basic biomedical science, bioengineering, and behavioral sciences. These initiatives have been accompanied by sustained investments in […]
Center for Molecular Epidemiology
Establishing the Center for Molecular Epidemiology, Center for Biomedical Research Excellence (COBRE) has transformed research in the field of molecular epidemiology at Dartmouth. As the only Center for Molecular Epidemiology in northern New England, and one of the only COBRE programs nationally with this focus, we have successfully recruited and mentored early career investigators who […]
The Delaware Comprehensive Sickle Cell Research Center
The Delaware Comprehensive Sickle Cell Research Program (a consortium between A.I. DuPont Hospital for Children and Delaware State Univ.) will build upon strengths in Biomedical Research, clinical care and recent recruitments to create a sustainable infrastructure supportive of target investigators and state-of-the art research. Three Target Investigator proposals and two Pilots comprise a well balanced […]
Delaware Center for Musculoskeletal Research
The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, […]
Renewal of Delaware Center for Neuroscience Research
The Delaware Center for Neuroscience Research, established in 2012 with a phase I COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD) that uniquely brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and […]
Mechanisms of Liver Injury and Diseases
Liver diseases including alcohol- and drug-induced liver injury, fatty liver disease, viral hepatitis, and liver cancer affects millions of people in he US. For the past 9 years the COBRE supported the recruitment of 15 junior faculty engaged in liver research and assisted in the development of highly successful core laboratories at the University of […]
Molecular Analysis of Disease Pathways
This proposal requests support to continue the development of the Center for Biomedical Research Excellence for Molecular Analysis of Disease Pathways (CMADP), which was established in 2012. The scientific theme of the CMADP is the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease. The Center […]