Center of Biomedical Research Excellence in CNS Metabolism
The University of Kentucky has been awarded a prestigious Centers of Biomedical Research Excellence (COBRE) grant to study central nervous system metabolism from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH). The $10.6 million, five-year grant will fund UK’s Center of Research in Central Nervous System Metabolism […]
IDeA Networks of Biomedical Research Excellence in Kentucky
The overarching goal of the Kentucky Institutional Development Award (IDeA) Network of Biomedical Research Excellence (KY INBRE) is to build capacity for health-related and biomedical research in the Commonwealth of Kentucky. We will build collaborative research and research-training community throughout the state. Our primary collaborative network is represented by two research-intensive universities, five state-supported and […]
Center of Research on Obesity and Cardiovascular Disease
Phase III of the Center for Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases (COCVD) will further develop and expand upon obesity as an underlying risk factor for the development of cardiovascular diseases, type 2 diabetes, cancer, and neurodegenerative diseases. Each of these diseases are rampant in Kentucky, and obesity has been identified as […]
Center for Excellence in Diabetes and Obesity Research
This application is to support Phase III of the COBRE-supported Diabetes and Obesity Center at the University of Louisville. The Center was established in 2008, with the central objective of supporting molecular, cellular, experimental, translational, and clinical investigations into the cardiovascular causes and consequences of diabetes and obesity. During Phase I and II, the Center […]
Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation
We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research and Innovation at the University of Kentucky (UK). CPRI will serve as a comprehensive multidisciplinary center focused on translational chemical biology [the nexus of chemical biology (the application of chemical biology principles to develop validated probe/models to advance our understanding of […]
Functional Microbiomics, Inflammation and Pathogenicity
In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances which have shaped our understanding of microbes as components of complex, polymicrobial, interactive communities. This microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances […]
Center for Cancer Immunology and Immunotherapy
The objective of this program is to establish a thematic multidisciplinary research center of excellence at the University of Louisville (UofL) named the Center for Cancer Immunology and Immunotherapy (CCII). The mission of the CCII is to conduct outstanding biomedical research that works towards harnessing the power of the immune system to eradicate cancer. There […]
University of Kentucky Center for Cancer and Metabolism
Cancer cell survival traits such as suppressed apoptosis, rapid cell cycling and proliferation, and the ability to metastasize from a primary location require extensive metabolic reprogramming of the tumor microenvironment. Intriguing new insights into the novel role of metabolic dysregulation in tumorigenesis and metastasis increasingly draw attention to currently understudied areas of cancer research: the […]
Hepatobiology and Toxicology COBRE
The University of Louisville (UofL) Hepatobiology and Toxicology (H&T) COBRE is a unique thematic center focused on liver research. The UofL H&T COBRE concentrates on the mechanisms and therapeutic strategies for multiple forms of liver disease/injury, including Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis—the most common liver disease in the US/worldwide, and is highly linked to the […]
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR Spectrometer
This proposal requests funds for the purchase of a state-of-the-art Bruker AVANCE NEO 600 MHz high-performance digital NMR spectrometer, which will be housed in the University of Kentucky (UK) PharmNMR Center located in the College of Pharmacy. The requested spectrometer offers capabilities that exceed by far those of the existing NMR instruments currently accessible to […]