Mississippi Center of Excellence in Perinatal Research
The Mississippi Center of Excellence in Perinatal Research (MS CEPR) at the University of Mississippi Medical Center is supported as part of the Center of Biomedical Research Excellence out of the National Institute of General Medical Sciences. Perinatal research encompasses the study of disease states that may occur during gestation and early post-natal development that […]
Center for Studies of Host Response to Cancer Therapy
The COBRE Center for Studies of Host Response to Cancer Therapy consists of faculty members who investigate biological mechanisms of and interventions in side effects of cancer therapy. Project Leaders receive financial and mentoring support for 3 years or until they receive significant other external research funding. Pilot Project Awardees receive funding from the Center […]
Appalachian Center for Cellular Transport in Obesity Related Disorders (ACCORD)
There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at Marshall University’s School of Medicine (MUSOM). Many of the innumerable health disparities of West Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At the epicenter of these disparities, MUSOM is well positioned to […]
West Virginia University Stroke COBRE
Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West […]
Mississippi INBRE
Mississippi IDeA Network of Biomedical Research Excellence (INBRE) is a network of colleges and universities, designed to build a biomedical research infrastructure in Mississippi. Our mission is to reach out to Mississippians in order to improve health throughout the state and to engage talented researchers and students in biomedical research projects that will increase the state’s […]
CYP2B6 inhibitors perturb proper distribution of lipids leading to obesity and fatty liver disease
Obesity, diabetes, and fatty liver diseases are at endemic proportions. Toxicological data indicates that the development of obesity is caused by more than just overeating, but also chemical exposure. Further, high-fat diet (HFD)-fed Cyp2b-null mice are obese compared to HFD-fed wildtype mice, primarily due to an increase in white adipose tissue (WAT) mass. Additionally, preliminary […]
SARS-CoV2 sequencing surveillance program for Upstate South Carolina
The goal of this project is to leverage the extensive COVID-19 testing program at Clemson University (CU) to detect and monitor emerging variants of the SARS-CoV2 virus by sequencing every positive sample. Variants of concern are emerging in our state of South Carolina. This is a serious public health threat because there is a real […]
Targeting sphingosine-1-phosphate receptor 2 as a novel therapeutic strategy for periodontitis
Periodontitis is a bacteria-driven inflammatory bone loss disease affecting 47% of adults in the United States.1 We were the first to demonstrate that sphingosine-1-phosphate receptor 2 (S1PR2) plays a key role in regulating the inflammatory bone loss response.18 S1PR2, a G protein-coupled receptor, is expressed in most tissues and mammalian cells.14,15 Previous studies19,21 showed that […]
Species-specific chromatin structure and its environmental interaction in craniofacial skeletal development andvariation using cichlid fishes
Variation in the craniofacial skeleton produces both a spectrum of unique faces and as well as clinical malformations. Congenital craniofacial anomalies are one of the most common birth defects. In addition to genetic changes, we are increasingly recognizing the importance of the physical packaging of DNA in the regulation of gene expression and development, and […]
South Carolina IDeA Networks of Biomedical Research Excellence
The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a state-wide network comprised of three Comprehensive Research Universities (CRUs) and ten Primarily Undergraduate Institutions (PUIs) whose goals are to enhance the biomedical research infrastructure and promote undergraduate research training in South Carolina while increasing access to research opportunities and careers in biomedicine […]