Surveillance genome sequencing to detect SARS-CoV-2 virus variants in Montana
Montana is a state with large rural and Tribal Nations populations. Both groups have been underrepresented in whole genome sequencing of SARS-CoV-2 variants and the state of Montana lags significantly behind the country as a whole in sequencing data available from patients infected with SARS-CoV-2. Given the emergence of dangerous SARS-CoV-2 variants with higher viral […]
A Multidisciplinary Research Network
MT INBRE IV has two overarching goals: 1) maintain and further develop the Montana research network and student pipeline, and 2) utilize this network to address the serious health disparities Montana’s rural and Native communities face. MT INBRE IV will support and mentor investigators from research universities, primarily undergraduate institutions (PUIs), and tribal colleges (TCs) […]
Macrophage Determinants of Retinal Regeneration
Macrophage Determinants of Retinal Regeneration The objective of this proposal is to understand microglia and macrophage ontogeny, dynamics, and endogenous roles in retinal degeneration and regeneration using the zebrafish as a model, a vertebrate organism capable of robust retinal regeneration following a variety of insults. Humans do not possess this regenerative capacity both in contexts […]
OSM-induced IL-6 and ER status in metastatic breast cancer
Despite new drugs and improved detection methods, the five-year survival rate for female breast cancer patients with distant metastases lingers at a dismal 27%. This is in part due to a critical lack of therapeutics specifically targeting triple negative breast cancer (TNBC), which is estrogen receptor-negative (ER-) progesterone receptor- negative (PR-) and HER2-negative (HER2-). This […]
Idaho Biomedical Research Collaborative in Emerging/Reemerging Infectious Disease
The COBRE Program Director (PD), Dr. Dennis Stevens, and the Idaho Veterans Research and Education Foundation (IVREF) seek to establish a well-equipped, multi-disciplinary, broadly-supported and ultimately self- sustaining Collaborative Biomedical Research Center of Excellence (COE) in Emerging/Reemerging Infectious Diseases at its partner institution – the Boise Idaho Veterans Affairs Medical Center (VAMC). Dr. Stevens is […]
Role of Distortion Energy in Fibroblast-Mediated Remodeling of Collagen Matrices
Dense connective tissue is composed of an abundant collagen network that is maintained and repaired by fibroblasts. These fibrous tissues are commonly injured and due to poor vascularity are slow to heal, leading to over 15 million hospital visits in the U.S. each year. It’s well established that dynamic mechanical stimulus will trigger fibroblasts to […]
Dynamically Controlled Plasma Scalpel for Wound Debridement
A variety of topical and systemic treatments exist to treat the chronic wounds and burns that afflict over 6 million patients annually in the U.S. However, wound infections/biofilms and necrotic tissue often exacerbate healing times and ultimately contribute to > $25 billion in added annual U.S. health care costs. Generally, wounds that fail to resolve […]
Idaho INBRE SARS-CoV-2 variant surveillance using viral genome sequencing and analyses
This Idaho INBRE Program Administrative Supplement will fund a surveillance study of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) in a unique study population. It will leverage the IDeA-built advanced-level bioinformatics infrastructure at the University of Idaho to sequence and analyze the genomes of SARS-CoV-2 circulating in the state. Idaho is primarily rural, poor, and […]
Idaho INBRE Program
The goal of the INBRE-4 Program is to continue to augment and strengthen Idaho’s capacity to do and sustain biomedical research. The Overall Component describes the organization and management plan for an Administrative Core, a Bioinformatics Core, a Student Program, a Developmental Research Project Program, and an Alteration and Renovation request. These Components will assist […]
Activity-dependent energy homeostasis at the presynaptic terminal
This work is relevant to both normal aging and pathologies like Alzheimer’s disease, where brain function is impaired due to defective mitochondrial respiration and loss of cellular energy. The long-term goal of this project is to ameliorate neurotransmission defects due to mitochondrial dysfunction, as a way to stop disease progression to later degenerative stages, increasing […]