Oncogenic mechanism of Sox2 in Rb-deficient tumors
The retinoblastoma tumor suppressor (Rb) is a central gene that has been implicated in the formation of multiple solid tumors. It does so by both the regulation of cellular proliferation and driving cellular differentiation to establish cellular identity. Lack of Rb then leads to cancer, yet the mechanisms which underlie the pro- oncogenic consequences of […]
An interactive tool for in-depth and reproducible analysis of RNA-seq data
Bioinformatic analysis of large genomic datasets is a critical barrier for many biologists, especially those at smaller research institutions. Leveraging our team’s bioinformatics experience, our goal is to develop an interactive web application that can be used to easily translate RNA sequencing data into biological insights. We hypothesized that an integrated tool for reproducible, in-depth […]
South Dakota Biomedical Research Infrastructure Network
South Dakota Biomedical Research Infrastructure Network (SD BRIN), hosted by the Sanford School of Medicine of the University of South Dakota (USD) in Vermillion, SD, is the SD component of IDeA Networks of Biomedical Research Excellence (INBRE) funded by the NIH/NIGMS Institutional Development Award (IDeA) program since 2002. This proposal has evolved from insights gained […]
Surveillance for the Spread of COVID-19 Variants through South Dakota
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has currently caused over 30 million illnesses and 550,000 deaths in the United States. Variants that show changes in transmissibility (B.1.1.7 variant) and antigenic recognition (B.1.35 and P.1 variants) have recently emerged. The impact of these variants […]
Center for Pediatric Research CoBRE
The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children’s disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. […]
The Role of LPA1 in the Etiology of Periodontal Disease
Lysophosphatidic acid (LPA) signaling has the potential to be of therapeutic value in periodontal disease (PD). LPA is central to homeostasis and pathophysiology, existing in bodily fluids at low levels in health, and becoming elevated in inflammation and pathology. Key to periodontal disease (PD), LPA is essential to all aspects of bone biology and inflammation […]
Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer
Pancreatic cancer (PC) is lethal with a five-year survival rate of less than 9.2 % and a median survival of 5-6 months. The limited efficacy of mono-therapies has led to the exploration of combination therapies with limited success because of challenges associated with dose-limiting side effects, drug-associated toxicities, drug resistance, and poor pharmacokinetics. Importantly, these […]
Nebraska Research Network in Functional Genomics
Overall Component Project Summary The mission of the Nebraska IDeA Networks of Biomedical Research Excellence (NE-INBRE) is to stimulate and develop biomedical research capacity at institutions of higher education in Nebraska. The NE-INBRE is structured around two major components: primarily undergraduate institutions (PUIs) and PhD granting research institutions (RIs). Support for each PUI consists of: […]
Rhode Island IDeA Network of Biomedical Research Excellence
The overarching goal of Rhode Island-IDeA Network of Biomedical Research Excellence (RI-INBRE) is to improve institutional capacity for biomedical research excellence and to expand student experiential training opportunities in the State of Rhode Island. We will accomplish this goal by growing statewide institutional research capacity, supporting early career research faculty development, and by providing structured […]
An experimental evaluation of e-cigarettes in young adults: Reinforcement enhancement and devaluation by nicotine
One concern about e-cigarettes is their abuse potential; however, we know of no systematic study of this in a young adult population. Abuse-liability assessments traditionally include the analysis of positive subjective effects and of self-administration, but these may fall short of accurately characterizing the abuse potential of tobacco products because recent preclinical studies indicate some […]