Center for Integrative Neuroscience
Overall This proposal is continue the development of a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Nationally, advances in the neurosciences are proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The COBRE at UNR was established to synergize and elevate […]
Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System
The goal of this new Phase I Center of Biomedical Research Excellence (COBRE) proposal is to establish and develop a new interdisciplinary research Center within the University of Nevada, Reno (UNR), and the UNR School of Medicine (UNR Med) that is focused on fundamental molecular and cellular signal transduction mechanisms within the cardiovascular system. This […]
Autophagy, Inflammation and Metabolism in Disease Center
Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health […]
University of New Mexico Center for Metals in Biology and Medicine
Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, […]
Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders
This Phase III (P-III) COBRE project will extend the cores that have been successfully leveraged in our Phase I (P-I) and Phase II (P-II) COBRE projects and sustain these unique resources in New Mexico through the im- plementation of a business plan. Over the past eight years we have built up infrastructure and created a […]
University of New Mexico Center for Brain Recovery and Repair
Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or […]
Mammalian Hibernation Research- A Path Towards a Center for Transformative Research in Metabolism
Overall This application is in response to PAR-16-415, Centers of Biomedical Research Excellence (COBRE) (P20). The proposed phase 1 center (P1C) is built on a strong foundation and long-term commitment to hibernation research at the University of Alaska’s Institute of Arctic Biology (IAB). The objective of the P1C is to use the expertise at IAB, […]
Pacific Center for Emerging Infectious Diseases Research
Established in 2003, the Pacific Center for Emerging Infectious Diseases Research, a translational science center of excellence supported by funding from the Centers of Biomedical Research Excellence (COBRE) component of the Institutional Development Award (IDeA) program, seeks to develop and deploy rapid diagnostics, improved therapeutics and affordable vaccines for new, emerging and re-emerging infectious diseases […]
IBR-COBRE Phase III
Overall Component Approximately 70,000 babies born in the U.S. in 2015 were conceived by artificial reproductive technologies (ART), which involves one of two techniques: in vitro fertilization (IVF) in which the sperm fertilizes the egg in vitro, or intracytoplasmic sperm injection (ICSI) in which the sperm is injected into the egg using micromanipulation. The rapid […]
Center for Translational Research on Aging
Kuakini Medical Center (Kuakini) proposes to develop a multidisciplinary Hawai’i-based Center of Biomedical Research Excellence (COBRE) for translational research on aging. This Center will draw on the most promising junior investigators from across the state with cross-institutional and interdisciplinary collaborative efforts between Kuakini, the University of Hawaii John A. Burns School of Medicine (JABSOM), and […]