Brian Bothner, Montana, Professor, Director of Montana INBRE, Molecular footprints at the boundary where chemistry becomes biology
Research Interests:
Research in the Bothner lab has two main focuses: (1) Investigation of cellular response to stress using chemical biology, proteomics, and metabolomics. (2) Assembly, stability, and dynamics of multi-subunit enzymes and nucleoprotein complexes. This research takes us from the atomic scale provided by high-resolution structural models of viruses and enzymes to complex interaction networks of nucleic acids, metabolites, and proteins that make up a living system. A diverse set of analytical, biophysical, biochemical, and chemical biology techniques are used in the discovery process. The Bothner lab is currently funded by the NIH, NSF, DOE, and USDA.