Oklahoma Center for Respiratory and Infectious Diseases

This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from […]

4.7T MRI for Translational Research Animal Facility

We are proposing to obtain a Bruker Biospin Advance Neo 47/40 USR pre-clinical MR imaging system with Paravision 360 software, including a 4.7T (Tesla) 40 cm magnet, gradient and shim coils (main and upgraded one for rodents), gradient/shim cooling, RF amplifiers, shim amplifier, Faraday cage, several RF volume and planar surface coils. For the proposed […]

Interdisciplinary Research in Vascular Biology

In this COBRE Phase III application, we will move to independence a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF). In Phases I and II, we fostered vascular biology research through a multidisciplinary approach. Mentoring launched the independent careers of outstanding junior investigators, who developed innovative new technologies, published […]

Oklahoma IDeA Network of Biomedical Research Excellence

This renewal application for the Oklahoma IDeA Network for Biomedical Research Excellence (OK-INBRE) proposes to further enhance the statewide research infrastructure and biomedical research capacity in Oklahoma by: i) building on our established OK-INBRE research network with a scientific focus to strengthen the lead and partner institutions’ biomedical research expertise and infrastructure, ii) increasing the […]

Center for Cellular Metabolism Research in Oklahoma

Altered cellular metabolism contributes to the pathogenesis of many common diseases, such as cardiovascular disease, cancer, diabetes, and autoimmune disorders, which are prevalent in Oklahoma. However, metabolism- related research resources and infrastructure are currently insufficient and scattered in Oklahoma. To address these deficiencies, this Center for Cellular Metabolism Research in Oklahoma (CMRO) Phase I COBRE […]

Cellular and Molecular Geroscience

There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE […]