Autophagy, Inflammation and Metabolism in Disease Center
Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health […]
University of New Mexico Center for Metals in Biology and Medicine
Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, […]
Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders
This Phase III (P-III) COBRE project will extend the cores that have been successfully leveraged in our Phase I (P-I) and Phase II (P-II) COBRE projects and sustain these unique resources in New Mexico through the im- plementation of a business plan. Over the past eight years we have built up infrastructure and created a […]
University of New Mexico Center for Brain Recovery and Repair
Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or […]
Improved Spatial Resolution in Magnetoencephalography with an Optically Pumped Magnetometer Array
The goal of this project is to optimize a novel strategy for magnetoencephalography (MEG) neuroimaging to substantially improve resolution and reduce cost. MEG is a non-invasive functional neuroimaging method to map brain activity that is useful for both research, e.g. functional brain mapping and clinical applications, e.g. presurgical epilepsy mapping. Commercial MEG systems using superconducting […]
SARS-CoV-2 Genomic Surveillance and Epidemiology in New Mexico
Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, […]
Deep sequencing SARS-CoV-2 samples from New Mexico to interrogate immunological selection on genetic variants
Although vaccination has blunted the impact of the SARS-CoV-2 pandemic in several countries, the future impact of this virus will depend on its transmissibility, virulence, and ability to evade naturally-acquired and vaccine- mediated immunity. All three phenotypes are currently in flux due to the evolution and spread of novel SARS- CoV-2 variants of concern. Importantly, […]
New Mexico IDeA Networks of Biomedical Research Excellence
This project is a continuation of the New Mexico Idea Network of Biomedical Research Excellence (NM- INBRE), a statewide network that promotes biomedical and community-based research and training through scientific research in the following thematic areas: structure and function of biomolecules, cell and organism, pathogens, and population and community health. The network includes nine institutions […]
Effect of Vaping on Lung Immunity
Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health […]