Personalized Medicine in Nevada- COBRE
OVERALL Society is progressing beyond ?trial-and-error medicine? into a new data-driven era wherein one’s genetic makeup is used to improve accuracy in medical diagnosis, prognosis, and treatment [1,2]. In President Barack Obama’s State of the Union Address on January 20, 2015, he mentioned the promise of, and future investment in, personalized medicine. Many experts, including […]
Center for Integrative Neuroscience
Overall This proposal is continue the development of a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Nationally, advances in the neurosciences are proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The COBRE at UNR was established to synergize and elevate […]
Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System
The goal of this new Phase I Center of Biomedical Research Excellence (COBRE) proposal is to establish and develop a new interdisciplinary research Center within the University of Nevada, Reno (UNR), and the UNR School of Medicine (UNR Med) that is focused on fundamental molecular and cellular signal transduction mechanisms within the cardiovascular system. This […]
Circadian disruption and consequences of light pollution
Project Summary Two-thirds of the world’s populated areas are currently above the threshold set for light pollution. It is clear from decades of research that light is the most important time cue for the regulation of circadian rhythms. Circadian clocks can be reset by external light cues, and light pulses at night can shift […]
Smooth Muscle Plasticity
In this Phase III COBRE we will continue to develop the thematic focus: Smooth Muscle Plasticity, by continuing and enhancing Core laboratory services developed during COBRE Phases l&ll. Smooth muscles are complex tissues containing multiple cell types. Treating these muscles as homogenous tissues has been a common way to evaluate gene expression and the changes […]
Activity-dependent energy homeostasis at the presynaptic terminal
This work is relevant to both normal aging and pathologies like Alzheimer’s disease, where brain function is impaired due to defective mitochondrial respiration and loss of cellular energy. The long-term goal of this project is to ameliorate neurotransmission defects due to mitochondrial dysfunction, as a way to stop disease progression to later degenerative stages, increasing […]
Nevada IDeA Networks of Biomedical Research Excellence
Overall Network Organization and Management Plan – Abstract In this proposal the NV INBRE will continue to pursue the goals of enhancing biomedical research infrastructure, research competitiveness, training and workforce development throughout the state of Nevada. The specific focus of this research is Cell Growth and Differentiation. Every two- and four-year teaching college and university […]
Clinical and Translational Research Infrastructure Network IDeA-CTR
The diverse Mountain West (MW) population continues to be plagued by high rates of health disparities (HD) and lower life expectancy rates when compared to the rest of the US1. The MW Clinical and Translational Research Infrastructure Network (CTR-IN) was established in 2013. During the last 4 years, we have created an impactful and transformative […]