Harnessing Movement Variability to Treat and Prevent Motor Related Disorders
In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the […]
Recognition and recruitment of RNA viruses into RNA silencing pathways
In eukaryotes, RNA silencing is a conserved mechanism of gene regulation and has essential antiviral roles in in plants, nematodes, and insects. Antiviral RNA silencing is triggered by viral dsRNA and is characterized by the accumulation of small interfering RNAs (siRNAs) derived from viral RNA (primary siRNAs) formed by Dicer- like proteins (DCL). Features of […]
The Role of LPA1 in the Etiology of Periodontal Disease
Lysophosphatidic acid (LPA) signaling has the potential to be of therapeutic value in periodontal disease (PD). LPA is central to homeostasis and pathophysiology, existing in bodily fluids at low levels in health, and becoming elevated in inflammation and pathology. Key to periodontal disease (PD), LPA is essential to all aspects of bone biology and inflammation […]
Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer
Pancreatic cancer (PC) is lethal with a five-year survival rate of less than 9.2 % and a median survival of 5-6 months. The limited efficacy of mono-therapies has led to the exploration of combination therapies with limited success because of challenges associated with dose-limiting side effects, drug-associated toxicities, drug resistance, and poor pharmacokinetics. Importantly, these […]
Nebraska Research Network in Functional Genomics
Overall Component Project Summary The mission of the Nebraska IDeA Networks of Biomedical Research Excellence (NE-INBRE) is to stimulate and develop biomedical research capacity at institutions of higher education in Nebraska. The NE-INBRE is structured around two major components: primarily undergraduate institutions (PUIs) and PhD granting research institutions (RIs). Support for each PUI consists of: […]