Center for Population Health Research
It is well understood that rural populations, especially rural children, suffer disproportionately from several chronic diseases and risk factors that adversely impact quality of life. For example, rurality is associated with higher infant mortality, increased rates of lower respiratory tract infection hospitalization among infants and young children and lower rates of early childhood vaccinations for […]
Biomolecular Structure and Dynamics
The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics at the University of Montana (CBSD COBRE) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. CBSD faculty members are drawn from the basic and biomedical sciences […]
Center for American Indian and Rural Health Equity
The mission of the Center for American Indian and Rural Health Equity (CAIRHE) is to reduce significant health disparities in Native and rural communities across Montana while developing junior faculty into a multidisciplinary cohort of independent health equity investigators. The Center achieves its mission through community-based participatory research (CBPR) and public health interventions that are […]
Characterizing the contribution of trogocytosis to T Follicular Helper differentiation and humoral immune responses
Recognition of cognate MHC class II:peptide complexes by CD4+ T cells triggers large-scale molecular rearrangements at the T- antigen presenting cells (APC) interface forming a structure called the immune synapse. At the synapse, T cells capture large membrane fragments and associated proteins from the APC in a process termed trogocytosis. While this phenomenon has the […]
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in Montana
Montana is a state with large rural and Tribal Nations populations. Both groups have been underrepresented in whole genome sequencing of SARS-CoV-2 variants and the state of Montana lags significantly behind the country as a whole in sequencing data available from patients infected with SARS-CoV-2. Given the emergence of dangerous SARS-CoV-2 variants with higher viral […]
A Multidisciplinary Research Network
MT INBRE IV has two overarching goals: 1) maintain and further develop the Montana research network and student pipeline, and 2) utilize this network to address the serious health disparities Montana’s rural and Native communities face. MT INBRE IV will support and mentor investigators from research universities, primarily undergraduate institutions (PUIs), and tribal colleges (TCs) […]
American Indian – Alaska Native Clinical and Translational Research Center
The American Indian-Alaska Native Clinical and Translational Research Center (AI-AN CTRC) has the goal of developing the capacity of Montana and Alaska to address the unique problems these state’s Native communities face in health disparities. AN-AI-AN CTRC will increase numbers of, train, support, and mentor investigators from AK and MT through research service cores and […]