Molecular Center of Health and Disease
Molecular Center of Health and Disease The mission of the Molecular Center of Health and Disease (MCHD) is to employ innovative molecular and physiological approaches to study health, onset and progression of disease, and interaction with pathogens, with the goal of understanding the breadth of information from the molecular level to the whole organism. […]
Mississippi Center of Excellence in Perinatal Research
The Mississippi Center of Excellence in Perinatal Research (MS CEPR) at the University of Mississippi Medical Center is supported as part of the Center of Biomedical Research Excellence out of the National Institute of General Medical Sciences. Perinatal research encompasses the study of disease states that may occur during gestation and early post-natal development that […]
Mississippi INBRE
Mississippi IDeA Network of Biomedical Research Excellence (INBRE) is a network of colleges and universities, designed to build a biomedical research infrastructure in Mississippi. Our mission is to reach out to Mississippians in order to improve health throughout the state and to engage talented researchers and students in biomedical research projects that will increase the state’s […]
Glycoscience Center of Research Excellence
The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a Phase I Center of Biomedical Research Excellence. Glycoscience is an essential and rapidly emerging field of biomedical science, and the challenging nature of glycoscience research requires tools and expertise that are not commonly found in the biomedical research community. Moreover, […]
New Inhibitors Targeting HIV-1 Integrase During Viral Maturation
HIV-1 integrase (IN) is a validated clinical target and is essential for viral replication. During the early steps of infection, tetrameric IN associates with two viral DNA ends and catalyzes their integration into the host chromosome. A new class of allosteric IN inhibitors (ALLINIs) has been reported to inhibit enzyme function by promoting aberrant IN […]
Rational design of an adhesin-based pneumococcal vaccine targeting colonization
Currently licensed pneumococcal conjugate vaccines have been successful in preventing invasive disease; however, overall colonization rates have remained fairly constant and serotype replacement by non-vaccine serotypes is now common. This along with other weaknesses points to a need for a broadly protective protein-based vaccine. Current protein candidates for such a vaccine have primarily been identified […]
Hypertension and Neuroinflammation during Pregnancy – The Impact on Maternal Behavior and Offspring Neurodevelopment
Wallace, Kedra Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome affect 10-20% of women with severe preeclampsia. Studies have identified HELLP syndrome as a condition of pregnancy in which women are affected with hypertension, neurological compromise, immune system dysregulation, and dysregulation of the soluble placental factors, sFlt-1 and sEndoglin, which are significantly increased compared […]
Myxobacterial predatory antimicrobial production in response to quorum sensing signal interception
Project Summary The 30-year absence of a clinically approved natural product-derived antibiotic with a novel scaffold demonstrates the dire need for unique methods to access new antimicrobial scaffolds and activities. However, the recent surge in scrutiny of microbial genomes provides evidence to indicate that an abundance of chemical scaffolds hidden within nascent biosynthetic pathways (BSPs) […]
Center of Biomedical Research Excellence in Pathogen Host Interactions
The Phase I COBRE at Mississippi State University (MSU) has catalyzed a transformation in the biomedical research enterprise, particularly in the research focus area of the COBRE, pathogen-host interactions. In the CVM Basic Sciences Department, where most COBRE investigators worked, the research culture has changed; 19 of 20 faculty members now have competitive extramural funding. […]
Cardiorenal and Metabolic Diseases Research Center
Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are […]