Extracellular Regulation of Cellular Behavior: Maine COBRE
The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation […]
Northern New England Clinical and Translational Research Network
The mission of the Northern New England Clinical and Translational Research (NNE-CTR) Network is to develop and sustain a clinical and translational research infrastructure that supports improvement in rural and community health for inhabitants in the IDeA states of Maine, New Hampshire and Vermont. This goal will be accomplished through complementary and synergistic collaborations of […]
Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function
Treatment of chronic pain continues to rely on old drugs such as gabapentinoids, reuptake blockers and opioids, all of which have severe side effects that diminish quality of life. Tolerance develops to opioids with chronic use, and an increase in opioid prescriptions has contributed to the growing opioid addiction epidemic. There is an urgent need […]
Comparative Biology of Tissue Repair, Regeneration and Aging
Regeneration of damaged and lost tissues is limited in humans and other mammals. However, robust regeneration is the norm for numerous diverse invertebrates and lower vertebrates. COBRE Phase I, Comparative Biology of Tissue Repair, Regeneration and Aging, played a central role in establishing and growing the Kathryn W. Davis Center for Regenerative Biology and Medicine […]
Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities
Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care […]
Mesenchymal and Neural Regulation of Metabolic Networks
Whole body metabolism is regulated by the integration of multiple organ systems, including adipose tissue, the skeleton, and bone marrow. Imbalance in the regulation of these tissues leads to chronic disorders such as obesity and osteoporosis. Adipocytes and osteoprogenitor cells share a common mesenchymal precursor, and link these two highly prevalent diseases. Mesenchymal progenitors are […]
Neonatal Trauma Alters Subsequent Fear and Sensory Function via Changes in Limbic CRF and CORT
There is now agreement that early life pain and stress are risk factors for subsequent changes in emotional, mood and sensory systems. Nevertheless, painful events continue to occur in the context of neonatal intensive care units (NICU) and other preventable settings. Similarly, a variety of less controllable stressful situations, such as suboptimal parenting conditions, also […]
Comparative Functional Genomics INBRE in Maine
The Maine IDeA Network of Biomedical Research Excellence (INBRE) is a collaborative network of Maine educational and research institutions led by the MDI Biological Laboratory and sponsored by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH). Maine INBRE members also include Bates College, Bowdoin College, Colby College, College of the Atlantic, The Jackson Laboratory, Southern Maine Community […]