Cardiorenal and Metabolic Diseases Research Center
Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are […]
Louisiana Biomedical Research Network (LBRN)
The overall goal of this INBRE renewal application is the facilitation of quality biomedical research activities throughout the State of Louisiana with an emphasis on building research capacity and workforce development. Starting with 2016, overall operations have been re-organized to maximize effectiveness and impact. Briefly, these include: 1) Direct engagement of the Steering Committee members […]
Regulation of Ocular Angiogenesis by microRNAs
Regulation of Ocular Angiogenesis by microRNAs: Anti-VEGF therapy is the current mainstay for treating wet age-related macular degeneration (AMD). The efficacy of anti-VEGF therapy is still limited, and some patients failed to respond to the treatment. No drug is currently available for subretinal fibrosis associated with AMD. Therefore, there is a great need for developing […]
Immunotherapy of KPC Infection
Immunotherapy of KPC Infection: A continued and emerging threat to human health are multi-drug resistant bacterial infections. Among these threats, carbapenemase producing strains of Klebsiella spp has been recognized by the World Health Organization and the Centers for Disease Control has a global threat to human health particularly in the hospital setting. Clinically these infections […]
Effects of E-Cigarettes on the Lung Metabolome in People Living with HIV
The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center (PBRC) is the lead LA CaTS institution and will continue to partner with Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO) and Tulane University Health Sciences […]
JAK/STAT signaling, peripheral insulin resistance, and pathogenesis in the high fat diet model of obesity in Drosophila melanogaster
One major pathogenic mechanism in obesity is aberrant endocrine signaling, which is exemplified by insulin resistance. Once insulin resistance develops in obesity, hyperlipidemia and hyperglycemia can result, which drives forward pathogenesis. During obesity, macrophages are known to modulate insulin sensitivity through the release of cytokines, among them Interleukin-6 (IL-6). IL-6 is a JAK/STAT ligand, which […]
Southeast Xlerator Network
The Southeast XLerator Network proposes to create a networked and easily accessible regional technology transfer accelerator hub (“XLerator Hub” or “Hub”) to share best practices, disseminate education content, and offer products, services, facilities and other resources connected through both physical and online platforms for innovators and trainees in the Southeast IDeA states. Led by XLerate […]
SARS-CoV-2 Genomic Surveillance in North Louisiana
Viral genomic surveillance is critical for identification of SARS-CoV-2 variants that exhibit biological characteristics of concern for public health, such as escape from humoral immunity, enhanced transmissibility, and/or increased pathogenic potential. This competitive revision proposal represents a collaboration between two LSU Health Shreveport (LSUHS) CoBRE’s (Center for Redox Biology and Cardiovascular Disease [CRBCD] and Center […]
Mentoring Obesity and Diabetes Research in Louisiana
Mentoring Obesity and Diabetes Research in Louisiana: Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as “metabolic syndrome”. Our Center of Biomedical Research Excellence (COBRE) at the Pennington […]
Mentoring in Cardiovascular Biology
Mentoring in Cardiovascular Biology: The objective of our Phase IIl Center of Biomedical Research Excellence (COBRE) program is to continue to provide the strong infrastructure, core laboratory support, and collegial scientific environment necessary to mentor outstanding investigators and foster collaborations within the multidisciplinary and interdepartmental effort i cardiovascular biology at the Louisiana State University Health […]