Center for Microbial Pathogenesis and Host Inflammatory Responses
Addressing infectious diseases in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in […]
The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast Cancer
West Virginia is a state that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West […]
West Virginia IDeA Network of Biomedical Research Excellence
West Virginia is a state that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West […]
West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research
The emergence of a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has resulted in human disease (COVID-19) that has swept the globe in pandemic proportions with more than eight million confirmed cases and >440,000 deaths to date. Surges of COVID-19 have occurred throughout the United States (US) with urban […]
PM2.5 from Fracking Operations Induces Microvascular and Mitochondrial Dysfunction
The production of shale gas, and the development of wells using horizontal drilling and hydraulic fracturing technology, is a major driver of the U.S. economy. The process of preparing well pads for completion of the work creates a complex mixture of airborne toxicants that includes elevated concentrations of particulate matter (PM), ultrafine particles (UFPs) from […]
Coaching End-of-Life Palliative Care for End-Stage Heart Failure Patients and Their Family Caregivers in Rural Appalachia
Project Summary Heart failure (HF) afflicts 6.5 million Americans with devastating consequences to patients and their family caregivers especially during severe symptoms in the long-lasting end-stage. Families are rarely prepared for HF’s devastating consequences. West Virginia (WV), a large rural Appalachian region, has the highest HF death rates in the U.S. NIH designated Appalachia a […]
Susceptibility and Resilience to Adverse Childhood Experiences: A Role for Perineuronal Nets
Over 60% of children experience severe stress and are exposed to traumatic events including interpersonal violence, sexual abuse, accidents, and injuries – adverse childhood experiences – but there is a mismatch between their exposure to these experiences and the prevalence of subsequent psychopathology. This mismatch, in which most children who experience traumatic events do not […]
Tumor Microenvironment CoBRE
The efforts described in this CoBRE application will support the development of a Center of Excellence within the West Virginia University Health Sciences Center (WVU HSC) that will focus on studies of the tumor microenvironment (TME), designated the TME CoBRE. The overarching critical need for continued emphasis in this area is driven, in part, by […]
Advancing Competitive Biomedical Research in Puerto Rico
This renewal application of the Puerto Rico IDeA Networks of Biomedical Research Excellence (PR-INBRE) will reinforce the original goal to strengthen the biomedical research capacity in Puerto Rico by serving as a platform for conducting multidisciplinary research. This objective will be augmented by the support of four thematic focus areas: Neuroscience, Molecular Medicine, Drug Development, […]
Hispanic Alliance for Clinical and Translational Research
Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. The current application is to support the development of Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance), which aims to build on the existing infrastructure of […]