Center of Biomedical Research Excellence in Cardiovascular Health
Cardiovascular diseases (CVD) such as heart disease, heart failure, and stroke remain the number one cause of death in the U.S. for both men and women. CVD affect Delawareans at a rate significantly above the national average. According to the Centers for Disease Control, Delaware is not even in the top half (i.e., better half) […]
Disc mechanics and altered loading in degeneration
The function of the intervertebral disc is mechanical. but disc pathology and LBP is currently evaluated in terms of structural changes, “structural degeneration (s-degen)”, observed from static images, and not in terms of mechanical function changes. While s-degen is considered to be related to pathology, it has had little clinical success discriminating pathology from natural […]
Center for Pediatric Research
The overall objective of this proposal is to build on the success of COBRE phase I and II grants, as well as 3 ARRA supplements. Thus, the goal of Phase III is to sustain infrastructure cores, mentorship programs, and pilot project programs, in order to provide the Center for Pediatric Research (CPR) the resources to […]
Molecular Design of Advanced Biomaterials
We propose to build on the success of COBRE phase I and phase II awards to establish four research cores that will provide the infrastructure to take our Center to the next level. In addition, COBRE III will provide a mechanism for pilot research projects to continue to develop vibrant teams of investigators in biomaterials […]
Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in Delaware
In this project, our team seeks to develop and evaluate a unique predictive modeling approach that can be applied to the spread of SARS-CoV-2 and subsequently adapted to address other emergent infectious diseases. Robust and accurate predictive models are needed to allow healthcare and public health experts to devise and evaluate interventions for controlling viral […]
Delaware INBRE
Overall The overall mission of the Delaware INBRE (DE-INBRE) program is to further grow a collaborative, multidisciplinary biomedical research network in Delaware that creates and supports sustainable collaborative research programs that address strategic health issues for the State, embraces diversity, and produces a positive impact on Delaware’s workforce and economy. The DE-INBRE network consists of […]
Expanding Excellence in Developmental Biology in Oklahoma
Our overall goal is to strengthen our Developmental Biology COBRE by mentoring five newly-recruited investigators, each studying important questions in Developmental Biology with translational implications. We will build upon our success in Phase I when our COBRE Investigators made important discoveries resulting in 53 published papers (many in high-impact journals), 91 presentations at invited seminars […]
Oklahoma Shared Clinical and Translational Resources
An Oklahoma born in 2010 has the fifth lowest life-expectancy in the US and American Indians have the shortest, 7.3 years less than the US average. Cancer, diabetes, cardiovascular disease, arthritis, and autoimmunity are leading causes of disability and early mortality, serving as sources of major health disparities in Oklahoma and other IDeA-states. Along with […]
Mentoring Diabetes Research in Oklahoma
Oklahoma is one of the states in the US with the highest prevalence of diabetes, with 10% of the population affected. Diabetes is particularly prevalent among Native American communities, where it affects up to 40% of older individuals in some tribes. Thus, diabetes and its complications constitute a major threat to the working- age and […]
Oklahoma Center for Respiratory and Infectious Diseases
This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from […]