Rural Drug Addiction Research Center
The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While drug addiction affects every region of the country, most information about drug use comes from large urban areas. Emerging data on rural addiction and its harms justify greater […]
Nebraska Center for Molecular Target Discovery and Development
Overall Center Organization and Management Plan The goal of the Nebraska Center for Molecular Target Discovery and Development is to establish and expand physical and intellectual resources at the University of Nebraska Medical Center (UNMC) and the University of Nebraska system that will catalyze the ability of its faculty to define, validate, and develop potential […]
Translational Hearing Center
Overall Plan for the Translational Hearing Center This Center of Biomedical Research Excellence (COBRE) application is to establish the Translational Hearing Center, administered by centrally-located Creighton University, with Boys Town National Research Hospital (BTNRH) and the University of Nebraska Medical Center (UNMC), as institutional partners. Our overall goal is to build a critical mass of […]
Nebraska Center for Integrated Biomolecular Communication
The University of Nebraska-Lincoln (UNL) seeks to foster collaborative interdisciplinary research to enhance its biomedical research infrastructure in the molecular life sciences. Building on the success of two prior UNL Centers of Biomedical Research Excellence (COBREs), it is proposed to establish the Nebraska Center for Integrated Biomolecular Communication (CIBC). The proper regulation of biomolecular communication […]
Harnessing Movement Variability to Treat and Prevent Motor Related Disorders
In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the […]
COBRE Center for Antimicrobial Resistance and Therapeutic Discovery
Overall Resistance to antimicrobial therapies is a national and international crisis that threatens clinical practice from fundamental primary care to the most advanced medical interventions such as cancer chemotherapy and organ transplantation. Much of what we take for granted in clinical medicine could become too risky as microorganisms have become increasingly resistant to our newest […]
Center for Central Nervous System Function
Purposeful human behavior requires attention, decisions and construction and production of abstract sequences, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. In a general and even a specific sense, attention, decision making and production of abstract sequences are key components of human mental activities. […]
Center for Addiction and Disease Risk Exacerbation
Substance use (SU) negatively affects the risk, management, progression, and outcomes of chronic disease and contributes to socio-economic and racial/ethnic disparities. Prevalence rates of medical conditions among patients with versus those without substance abuse disorders (SUDs) support this thesis. Furthermore, risks are exacerbated among those at risk for or who already have chronic medical conditions, […]
COBRE: Center for Computational Biology of Human Disease
We propose to establish and build the COBRE Center for the Computational Biology of Human Disease at Brown University and affiliated hospitals. The motivation for this effort lies in the joint promise that personalized genomic medicine and novel analyses of Big Data are key elements in the identification and treatment of human disease. Sequencing a […]
COBRE for Perinatal Biology
The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the […]