Dr. Peter R. Hoffmann is an established investigator who is the PI for Hawaii INBRE V Program Association, Immunology, Inflammation, Inflammation associated cancer. Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urshcitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. (2021). Upregulated ethanolamine phospholipid synthesis by selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metabol; Jan 20;47:101170. doi: 10.1016/j.molmet.2021.101170.Marciel MP, Khadka V, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter M, Hoffmann PR. (2018). Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget; Feb 3;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 2.Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR. (2018). Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med:Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6. PMID 29210197.Fredericks GJ, Hoffmann FW, Rose AH, Osterheld H, Hess FM, Mercier F, Hoffmann PR. (2014). Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/Selenoprotein K complex. Proc Natl Acad Sci;Nov 18;111(46):16478-16483.Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. (2013). Calpastatin prevents NF-B mediated hyperactivation of macrophages and attenuates colitis. J Immunol;Oct 1;191(7):3778-88.

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