Bongsup Cho, Ph.D., National Committee Member NAIPI, Program Director of RI-INBRE and Professor, University of Rhode Island College of Pharmacy, Kingston, Rhode Island, United States
Biography
The human genome is under constant assault from the environment. DNA-damage-induced mutations are known to trigger chemical carcinogenesis. It is important to understand the impact of DNA mutations on cancer initiation. Organic carcinogens such as arylamines produce bulky DNA adducts. These lesions are known to adopt three different conformational motifs: the major groove B-type (B), stacked (S), and the minor groove wedge (W). These conformational heterogeneities complicate mutationally and repair outcomes.
To this end, our laboratory has been studying the conformational dependence of DNA repair and mutation. We employ a wide range of spectroscopic, calorimetric, and chip-based technologies to probe adduct conformation. We are also passionate about using 3D Science Visualization technology that would help facilitate students’ learning of the molecular mechanisms of drug-macromolecular action.
To this end our laboratory has been studying the conformational dependence of DNA repair and mutation. We employ a wide range of spectroscopic, calorimetric, and chip-based technologies to probe adduct conformation. We are also passionate about using 3D Science Visualization technology that would help facilitate students’ learning of the molecular mechanisms of drug-macromolecular action.
Research
Cancer, DNA Damage, Repair, Replication, Mutation, DNA-adduct, Molecular Toxicology, Structural Biology, Chemical Biology, Per- and polyfluoroalkyl Substances (PFASs)