The Vermont Center for Cardiovascular and Brain Health (VCCBH) is an NIH funded Center for BioMedical Research Excellence (COBRE) that provides a platform to build sustainable research programs built on the exceptional potential of early career faculty. We are studying the vital health problems facing society: cardiovascular disease, stroke and cognitive impairment.
We are moving into our second year of NIH funding with great momentum, including the launch of this website! Our funded early career faculty are publishing in major journals like JCI, PNAS, and Journal of NeuroEngineering and Rehabilitation on topics ranging from control of cerebral blood flow to use of wearable technology to monitor patients recovering from stroke. We have a lineup of speakers slated for our Monthly Conference and Journal Clubs, and planning is underway for our Annual Symposium June 2-3, 2022. We encourage UVM junior faculty to watch for our call for applications for our $200,000 Early Career Pilot Grant Award.
Cardiovascular disease is the #1 cause of mortality in the United States and stroke is the #5 cause. Stroke is also the #1 cause of disability, and it, along with covert neurovascular disease including small vessel disease of the brain, leads to Vascular Cognitive Impairment and Dementia (VCID). Each year 800,000 Americans have a stroke and 720,000 Americans have myocardial infarction. There will be 75 million people with dementia by 2030 and 131 million by 2050. Direct annual costs of cardiovascular disease and stroke are $318 billion and dementia $277 billion. The American Heart Association issued a Presidential Advisory in 2017 highlighting the central role of cardiovascular health to brain health and cognitive function. Much of VCID is driven by increases in covert stroke and small vessel disease of the brain, research areas of expertise for the PIs of this application. To address these issues, this University of Vermont (UVM) Center on Cardiovascular and Brain Health (VCCBH) will leverage NIH funding and institutional commitment to convene multidisciplinary researchers across career stages to determine causes and suggest optimal treatments for cardiovascular and neurovascular disease, including stroke and VCID. We have selected four junior faculty (Project Directors, PDs), from three departments and two UVM colleges, through a rigorous selection process. The VCCBH will support the PDs’ transition to independence using a Strategic Mentoring Initiative (SMI), Faculty Development Program (FDP), and assistance and education from two new Core facilities. The SMI will employ multidisciplinary Mentor Teams, including Peer Mentors. The FDP will comprise several educational programs highlighted by an annual 2-Day Research Symposium, and an impactful Pilot Grant program (supported by institutional commitments) that will provide $200,000 to four interdisciplinary research teams of junior faculty. We will establish two new Core facilities: Study Design and Molecular Epidemiology, and Customized Physiology and Imaging. A pipeline of new project directors will be developed from a pool of 19 current candidates and five new junior faculty, who will be recruited with committed institutional support. Capstones of the Center will include continual quality evaluation, clear communication and commitment to diversity. By the completion of Phase I of funding, the Center will be on a strong path to sustainability in research excellence.
Vermont Center for Cardiovascular and Brain Health – Mary Cushman (grantome.com)