COBRE in Neurodevelopment and Its Disorders
COBRE in Neurodevelopment and Its Disorders PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to […]
South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
Overall – Abstract With Phase III COBRE support, the South Carolina Center in Oxidants, Redox Balance, and Stress Signaling (Redox COBRE) at the Medical University of South Carolina (MUSC) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in redox pathobiology. During Phases I and II, our Redox COBRE […]
South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)
The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a state-wide network comprised of three Comprehensive Research Universities (CRUs) and eleven Primarily Undergraduate Institutions (PUIs) whose goals are to enhance the biomedical research infrastructure and promote undergraduate research training in South Carolina while increasing access to research opportunities and careers in biomedicine […]
SC COBRE for Translational Research Improving Musculoskeletal Health
The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to enhance and expand the Biomedical Research capacity at Clemson University to promote outstanding multidisciplinary, collaborative, and translational research in bone and joint diseases. A new scientific concept for translational research, i.e. Virtual Human Trials, is to be implemented […]
Species-specific chromatin structure and its environmental interaction in craniofacial skeletal development andvariation using cichlid fishes
Variation in the craniofacial skeleton produces both a spectrum of unique faces and as well as clinical malformations. Congenital craniofacial anomalies are one of the most common birth defects. In addition to genetic changes, we are increasingly recognizing the importance of the physical packaging of DNA in the regulation of gene expression and development, and […]
SARS-CoV2 sequencing surveillance program for Upstate South Carolina
The goal of this project is to leverage the extensive COVID-19 testing program at Clemson University (CU) to detect and monitor emerging variants of the SARS-CoV2 virus by sequencing every positive sample. Variants of concern are emerging in our state of South Carolina. This is a serious public health threat because there is a real […]
CYP2B6 inhibitors perturb proper distribution of lipids leading to obesity and fatty liver disease
Obesity, diabetes, and fatty liver diseases are at endemic proportions. Toxicological data indicates that the development of obesity is caused by more than just overeating, but also chemical exposure. Further, high-fat diet (HFD)-fed Cyp2b-null mice are obese compared to HFD-fed wildtype mice, primarily due to an increase in white adipose tissue (WAT) mass. Additionally, preliminary […]
South Carolina IDeA Networks of Biomedical Research Excellence
The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a state-wide network comprised of three Comprehensive Research Universities (CRUs) and ten Primarily Undergraduate Institutions (PUIs) whose goals are to enhance the biomedical research infrastructure and promote undergraduate research training in South Carolina while increasing access to research opportunities and careers in biomedicine […]
Kv7 channels and heavy alcohol drinking
Excessive alcohol (ethanol) consumption is a hallmark characteristic of individuals with alcohol use disorder (AUD) and a risk factor for developing alcohol dependence. Mood and anxiety disorders that are often comorbid with AUD can hinder psychosocial treatment interventions and increase the risk of relapse. While current FDA approved medications are not effective in the general […]
Bioengineering Center for Regeneration and Formation of Tissues
This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center’s […]