Center for the Promotion of Cancer Health Equity (CePCHE)
PROJECT SUMMARY/ABSTRACT: OVERALL COBRE Center for the Promotion of Cancer Health Equity (CePCHE) Profound cancer health disparities, in urgent need of being addressed, exist between Puerto Rico and the mainland U.S. The University of Puerto Rico Comprehensive Cancer Center (UPRCCC), and the University of Puerto Rico (UPR), through its two urban graduate centers, UPR-Rio Piedras and […]
Center for Neuroplasticity at the University of Puerto Rico
The University of Puerto Rico (UPR) Medical Sciences Campus proposes to sustain and expand its COBRE Center for Neuroplasticity. The second phase of Center operation will significantly strengthen the research infrastructure of the institution and will impact biomedical investigation throughout the island. The specific aims of the COBRE Center for Neuroplasticity at the University of […]
Establishment of a multi-user high-performance MALDI ToF/ToF mass spectrometer in the University of Puerto Rico, Molecular Science Research Center
The main goal of this revised application is to purchase a high-performance MALDI ToF/ToF mass spectrometer at the University of Puerto Rico, Molecular Science Research Center (MSRC). Planning of this instrumentation proposal has brought together 16 scientists from three research centers (UPR-Rio Piedras, UPR-Medical Sciences, and Institute of Neurobiology in San Juan) in a common […]
A cross-talk between oxytocin and the endocannabinoids within the mesolimbic system regulates anxiety triggered by cocaine us
Oxytocin (OT) is a neuropeptide secreted by the hypothalamic paraventricular nucleus (PVN) and commonly associated with social behaviors, stress responses, and drug addiction. Previous studies have shown that OT has anxiolytic properties associated with cues in a cocaine-seeking behavior paradigm, but the underlying mechanism remains unknown. Clinical studies show that cocaine abuse has long-term effects […]
Roadmap for Intestinal Regeneration
Digestive diseases affect millions of Americans each year, and a significant number will die from them. The main culprits of these diseases are disrupted cellular mechanisms for homeostatic control and deficient repair mechanisms. Repair mechanisms play an important role in healing after natural events that damage the digestive tract and also after gastrointestinal surgery. Accordingly, […]
Advancing Competitive Biomedical Research in Puerto Rico
This renewal application of the Puerto Rico IDeA Networks of Biomedical Research Excellence (PR-INBRE) will reinforce the original goal to strengthen the biomedical research capacity in Puerto Rico by serving as a platform for conducting multidisciplinary research. This objective will be augmented by the support of four thematic focus areas: Neuroscience, Molecular Medicine, Drug Development, […]
Hispanic Alliance for Clinical and Translational Research
Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. The current application is to support the development of Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance), which aims to build on the existing infrastructure of […]