Metabolic Basis of Disease
Metabolic Basis of Disease: The overall goal of this new center is to facilitate the growth of young intellectual talent and build the scientific infrastructure that will promote biomedical research discoveries that will enhance our understanding of the metabolic aspects of different diseases. Specifically, we have identified four junior faculty with research interests in different, […]
Louisiana Biomedical Research Network (LBRN)
The overall goal of this INBRE renewal application is the facilitation of quality biomedical research activities throughout the State of Louisiana with an emphasis on building research capacity and workforce development. Starting with 2016, overall operations have been re-organized to maximize effectiveness and impact. Briefly, these include: 1) Direct engagement of the Steering Committee members […]
SARS-CoV-2 Genomic Surveillance in North Louisiana
Viral genomic surveillance is critical for identification of SARS-CoV-2 variants that exhibit biological characteristics of concern for public health, such as escape from humoral immunity, enhanced transmissibility, and/or increased pathogenic potential. This competitive revision proposal represents a collaboration between two LSU Health Shreveport (LSUHS) CoBRE’s (Center for Redox Biology and Cardiovascular Disease [CRBCD] and Center […]
JAK/STAT signaling, peripheral insulin resistance, and pathogenesis in the high fat diet model of obesity in Drosophila melanogaster
One major pathogenic mechanism in obesity is aberrant endocrine signaling, which is exemplified by insulin resistance. Once insulin resistance develops in obesity, hyperlipidemia and hyperglycemia can result, which drives forward pathogenesis. During obesity, macrophages are known to modulate insulin sensitivity through the release of cytokines, among them Interleukin-6 (IL-6). IL-6 is a JAK/STAT ligand, which […]
Effects of E-Cigarettes on the Lung Metabolome in People Living with HIV
The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center (PBRC) is the lead LA CaTS institution and will continue to partner with Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO) and Tulane University Health Sciences […]
Immunotherapy of KPC Infection
Immunotherapy of KPC Infection: A continued and emerging threat to human health are multi-drug resistant bacterial infections. Among these threats, carbapenemase producing strains of Klebsiella spp has been recognized by the World Health Organization and the Centers for Disease Control has a global threat to human health particularly in the hospital setting. Clinically these infections […]
Regulation of Ocular Angiogenesis by microRNAs
Regulation of Ocular Angiogenesis by microRNAs: Anti-VEGF therapy is the current mainstay for treating wet age-related macular degeneration (AMD). The efficacy of anti-VEGF therapy is still limited, and some patients failed to respond to the treatment. No drug is currently available for subretinal fibrosis associated with AMD. Therefore, there is a great need for developing […]
Tcf21 and visceral adipose tissue development and expansion
Tcf21 and visceral adipose tissue development and expansion: White adipose tissue (WAT) is divided into two categories, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), based on their anatomical locations. A specific positive correlation has been suggested between pathologic VAT expansion and insulin resistance, which makes VAT a potential target for treating metabolic diseases […]
Center for Redox Biology and Cardiovascular Disease
Project Abstract Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. According to the 2016 America’s Health Rankings Annual Report, Louisiana ranks 46/50 in cardiovascular deaths and 48/50 in heart disease placing it in the lowest categories of cardiovascular health […]
Center for Applied Immunology and Pathological Processes
Center for Applied Immunology and Pathological Processes: A properly functioning and effective immune system is needed to control infection by bacterial, viral and other pathogen invaders, growth of aberrant cells, as well as for proper embryonic development, wound healing, bone remodeling, and other normal homeostatic processes. Thus, understanding the innate and adaptive immune responses and […]