Convergent Engineering and Biomolecular Science
Abstract Text PROJECT SUMMARY ─ OVERALL Boise State University is an emerging research institution in the Mountain West. In the past 5 years, annual research awards have increased 58% to more than $65 million. The objective for the proposed COBRE in Convergent Engineering and Biomolecular Science (CEBS) is to enhance Boise State’s ability to contribute […]
COBRE Phase III Transitional Center
The Center of Biomedical Research Excellence for Research on Processes in Evolution at the University of Idaho is organized under the auspices of the Institute for Bioinformatics and Evolutionary Studies (IBEST). For the past 10 years, COBRE funding enabled IBEST investigators to conduct leading-edge interdisciplinary research in computational and evolutionary biology and to mentor early […]
Identification and Dynamics of SARS-CoV-2 Sequence Variants in Idaho
The first SARS-CoV-2 sequence published provided the foundation by which all currently approved detection methods and vaccines have been developed. However, variants of SARS-CoV-2 that carry multiple changes to their genome may enable the virus to evade detection and escape natural or vaccine-induced immunity, thwarting current abatement efforts. Additionally, variants that increase transmissibility, enhance disease […]
Center of Biomedical Research Excellence in Matrix Biology Phase II
The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. […]
Center for Modeling Complex Interactions
Biomedical problems are innately complex, and their solutions require input from many fields. Many centers focus on a single disease or organ system. By contrast, the Center for Modeling Complex Interactions focuses on an approach that can address many biomedical problems: team-based, interdisciplinary research centered around modeling. Our goal is to support and facilitate biomedical […]
Macrophage Determinants of Retinal Regeneration
Macrophage Determinants of Retinal Regeneration The objective of this proposal is to understand microglia and macrophage ontogeny, dynamics, and endogenous roles in retinal degeneration and regeneration using the zebrafish as a model, a vertebrate organism capable of robust retinal regeneration following a variety of insults. Humans do not possess this regenerative capacity both in contexts […]
Idaho Biomedical Research Collaborative in Emerging/Reemerging Infectious Disease
The COBRE Program Director (PD), Dr. Dennis Stevens, and the Idaho Veterans Research and Education Foundation (IVREF) seek to establish a well-equipped, multi-disciplinary, broadly-supported and ultimately self- sustaining Collaborative Biomedical Research Center of Excellence (COE) in Emerging/Reemerging Infectious Diseases at its partner institution – the Boise Idaho Veterans Affairs Medical Center (VAMC). Dr. Stevens is […]
Role of Distortion Energy in Fibroblast-Mediated Remodeling of Collagen Matrices
Dense connective tissue is composed of an abundant collagen network that is maintained and repaired by fibroblasts. These fibrous tissues are commonly injured and due to poor vascularity are slow to heal, leading to over 15 million hospital visits in the U.S. each year. It’s well established that dynamic mechanical stimulus will trigger fibroblasts to […]
Idaho INBRE SARS-CoV-2 variant surveillance using viral genome sequencing and analyses
This Idaho INBRE Program Administrative Supplement will fund a surveillance study of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) in a unique study population. It will leverage the IDeA-built advanced-level bioinformatics infrastructure at the University of Idaho to sequence and analyze the genomes of SARS-CoV-2 circulating in the state. Idaho is primarily rural, poor, and […]
Idaho INBRE Program
The goal of the INBRE-4 Program is to continue to augment and strengthen Idaho’s capacity to do and sustain biomedical research. The Overall Component describes the organization and management plan for an Administrative Core, a Bioinformatics Core, a Student Program, a Developmental Research Project Program, and an Alteration and Renovation request. These Components will assist […]