Center for Studies of Host Response to Cancer Therapy
The COBRE Center for Studies of Host Response to Cancer Therapy consists of faculty members who investigate biological mechanisms of and interventions in side effects of cancer therapy. Project Leaders receive financial and mentoring support for 3 years or until they receive significant other external research funding. Pilot Project Awardees receive funding from the Center […]
Center for Microbial Pathogenesis and Host Inflammatory Responses
Addressing infectious diseases in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in […]
Partnerships for Biomedical Research in Arkansas
This proposal will continue to pursue the primary goals of the Arkansas IDeA Network for Biomedical Research Excellence (INBRE) to expand biomedical research capacity in Arkansas. Building upon infrastructure developed during the earlier BRIN/INBRE phases, two research-intensive, lead institutions in the state—the University of Arkansas for Medical Sciences (UAMS) and the University of Arkansas, Fayetteville […]
Center for Musculoskeletal Disease Research
Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an […]
Center for Childhood Obesity Prevention
The goal of this application is to develop an integrated, interdisciplinary and translational Center for Childhood Obesity Prevention. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. Therefore, the immediate goal is to prevent the rise in Arkansas childhood obesity rates, with an ultimate goal of reducing childhood obesity rates […]
Center for Translational Pediatric Research
The Arkansas Children’s Hospital Research Institute (ACHRI) proposes to establish a thematic, multidisciplinary research center titled the Center for Translational Pediatric Research (CTPR). ACHRI is located at Arkansas Children’s Hospital, which is the only pediatric hospital in Arkansas; thus, providing a unique environment and clinical population to study pediatric diseases including cancer. Dr. Alan Tackett, […]
Mitochondrial Degeneration – the Root of Skeletal Muscle Atrophy
Muscle atrophy is a hallmark of many chronic diseases resulting in impaired function and reduced quality and quantity of life. However, current interventions to prevent muscle atrophy are not fully efficacious. Therefore, a critical need remains to fully elucidate mechanisms of muscle atrophy. We have evidence of muscle wasting in severe obesity associated with altered […]
Efficacy testing of an injectable matrix gel for the treatment of fatty muscle infiltration
Each year approximately 400,000 rotator cuff surgeries are performed in the United States. While operative techniques have improved, the failure rate remains unacceptably high (30-35%). A recognized risk factor for surgical failure is fatty muscle infiltration. The muscles of the rotator cuff undergo progressive fatty infiltration following tendon tear. While surgical techniques have been developed […]