Dynamically Controlled Plasma Scalpel for Wound Debridement
A variety of topical and systemic treatments exist to treat the chronic wounds and burns that afflict over 6 million patients annually in the U.S. However, wound infections/biofilms and necrotic tissue often exacerbate healing times and ultimately contribute to > $25 billion in added annual U.S. health care costs. Generally, wounds that fail to resolve […]
Idaho INBRE SARS-CoV-2 variant surveillance using viral genome sequencing and analyses
This Idaho INBRE Program Administrative Supplement will fund a surveillance study of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) in a unique study population. It will leverage the IDeA-built advanced-level bioinformatics infrastructure at the University of Idaho to sequence and analyze the genomes of SARS-CoV-2 circulating in the state. Idaho is primarily rural, poor, and […]
Idaho INBRE Program
The goal of the INBRE-4 Program is to continue to augment and strengthen Idaho’s capacity to do and sustain biomedical research. The Overall Component describes the organization and management plan for an Administrative Core, a Bioinformatics Core, a Student Program, a Developmental Research Project Program, and an Alteration and Renovation request. These Components will assist […]
Activity-dependent energy homeostasis at the presynaptic terminal
This work is relevant to both normal aging and pathologies like Alzheimer’s disease, where brain function is impaired due to defective mitochondrial respiration and loss of cellular energy. The long-term goal of this project is to ameliorate neurotransmission defects due to mitochondrial dysfunction, as a way to stop disease progression to later degenerative stages, increasing […]
Access to Kidney Transplantation in Minority Populations
Kidney transplantation (KT) is the optimal treatment for end-stage kidney disease (ESKD). It reduces mortality, improves quality of life, and costs less than dialysis. Previous research demonstrated significant disparities in ESKD and its treatment for members of disadvantaged groups [e.g., Hispanic/Latino (HL), American Indians (AI), low income]. Although HL and AI are referred for KT […]
American Indian – Alaska Native Clinical and Translational Research Center
The American Indian-Alaska Native Clinical and Translational Research Center (AI-AN CTRC) has the goal of developing the capacity of Montana and Alaska to address the unique problems these state’s Native communities face in health disparities. AN-AI-AN CTRC will increase numbers of, train, support, and mentor investigators from AK and MT through research service cores and […]
Clinical and Translational Research Infrastructure Network IDeA-CTR
The diverse Mountain West (MW) population continues to be plagued by high rates of health disparities (HD) and lower life expectancy rates when compared to the rest of the US1. The MW Clinical and Translational Research Infrastructure Network (CTR-IN) was established in 2013. During the last 4 years, we have created an impactful and transformative […]
Effect of Vaping on Lung Immunity
Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health […]
Center for Population Health Research
It is well understood that rural populations, especially rural children, suffer disproportionately from several chronic diseases and risk factors that adversely impact quality of life. For example, rurality is associated with higher infant mortality, increased rates of lower respiratory tract infection hospitalization among infants and young children and lower rates of early childhood vaccinations for […]
Biomolecular Structure and Dynamics
The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics at the University of Montana (CBSD COBRE) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. CBSD faculty members are drawn from the basic and biomedical sciences […]