PM2.5 from Fracking Operations Induces Microvascular and Mitochondrial Dysfunction
The production of shale gas, and the development of wells using horizontal drilling and hydraulic fracturing technology, is a major driver of the U.S. economy. The process of preparing well pads for completion of the work creates a complex mixture of airborne toxicants that includes elevated concentrations of particulate matter (PM), ultrafine particles (UFPs) from […]
West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research
The emergence of a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has resulted in human disease (COVID-19) that has swept the globe in pandemic proportions with more than eight million confirmed cases and >440,000 deaths to date. Surges of COVID-19 have occurred throughout the United States (US) with urban […]
West Virginia IDeA Network of Biomedical Research Excellence
West Virginia is a state that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West […]
The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast Cancer
West Virginia is a state that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West […]
Center for Microbial Pathogenesis and Host Inflammatory Responses
Addressing infectious diseases in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in […]
Partnerships for Biomedical Research in Arkansas
This proposal will continue to pursue the primary goals of the Arkansas IDeA Network for Biomedical Research Excellence (INBRE) to expand biomedical research capacity in Arkansas. Building upon infrastructure developed during the earlier BRIN/INBRE phases, two research-intensive, lead institutions in the state—the University of Arkansas for Medical Sciences (UAMS) and the University of Arkansas, Fayetteville […]
Center for Musculoskeletal Disease Research
Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an […]
Arkansas Integrative Metabolic Research Center
Project Summary for Overall Section of the Arkansas Integrative Metabolic Research Center The University of Arkansas – Fayetteville (U of A) is the flagship campus of the State of Arkansas but does not have active NIH COBRE funding on campus. A clear strength in biomedical research has emerged organically on campus, with the majority of […]
Center for Childhood Obesity Prevention
The goal of this application is to develop an integrated, interdisciplinary and translational Center for Childhood Obesity Prevention. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. Therefore, the immediate goal is to prevent the rise in Arkansas childhood obesity rates, with an ultimate goal of reducing childhood obesity rates […]
New Inhibitors Targeting HIV-1 Integrase During Viral Maturation
HIV-1 integrase (IN) is a validated clinical target and is essential for viral replication. During the early steps of infection, tetrameric IN associates with two viral DNA ends and catalyzes their integration into the host chromosome. A new class of allosteric IN inhibitors (ALLINIs) has been reported to inhibit enzyme function by promoting aberrant IN […]