Dr. Mylonakis is recognized for his research on the study of microbial pathogenesis and host responses. His studies have included clinical and laboratory studies and the use of mammalian and invertebrate model hosts.
These surrogate hosts fill an important niche in pathogenesis research and provide us with a unique opportunity to identify novel antimicrobial compounds and study basic, evolutionarily conserved aspects of microbial virulence and host response. His investigations have identified novel virulence factors, cross-kingdom evolutionarily conserved traits that are involved in host virulence and immune responses during fungal infection.
Taken in their totality, these results indicate that a common, fundamental set of molecular mechanisms is employed by pathogens against a widely divergent array of metazoan hosts. His research has resulted in >200 peer-reviewed scientific articles. Mylonakis has edited five books on infectious diseases and is the founding editor-in-chief of Virulence.
He is also working as Principal Investigator COBRE Center for Antimicrobial Resistance and Therapeutic Discovery, Rhode Island.