William R Green, Ph.D., The Elmer R. Pfefferkorn Professor of Microbiology and Immunology.

The primary interests of the lab focus on cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency. We have been studying resistance to endogenous AKR/Gross virus-induced leukemia mediated by cytotoxic T lymphocyte (CTL) responses. By use of “low leukemia” mouse strains, CTL that readily lyse AKR/Gross retrovirus-induced tumors have been generated. The CTL recognizes “type-specific” viral determinants with the major immunodominant viral peptide located in the transmembrane anchor protein encoded by the envelope gene. Other mouse strains of higher leukemia incidence are unable to generate such CTL responses. The mechanism of unresponsiveness includes both MHC-dependent mechanisms and apoptosis of effector CTL following interaction with FasL-expressing virus-infected cells.

He is also working as Principal Investigator of New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE), New Hampshire.

William R Green, PhD – Faculty Expertise Database – Geisel School of Medicine at Dartmouth