Brian Bothner

Brian Bothner,  Montana, Professor, Director of Montana INBRE, Molecular footprints at the boundary where chemistry becomes biology

Research Interests:

Research in the Bothner lab has two main focuses:

(1) Investigation of cellular response to stress using chemical biology, proteomics, and metabolomics.

(2) Assembly, stability, and dynamics of multi-subunit enzymes and nucleoprotein complexes.

This research takes us from the atomic scale provided by high-resolution structural models of viruses and enzymes to complex interaction networks of nucleic acids, metabolites, and proteins that make up a living system. A diverse set of analytical, biophysical, biochemical, and chemical biology techniques are used in the discovery process.

The Bothner lab is currently funded by the NIH, NSF, DOE, and USDA.

Brian Bothner (montana.edu)