Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. The current application is to support the development of Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance), which aims to build on the existing infrastructure of the Puerto Rico Clinical and Translational Research Consortia (PR-CTRC an RCMI-CTR) and the unique expertise on emerging infectious diseases and the study of disaster-related conditions and their impact on Health. The objective of the Alliance is to serve as the catalytic center to enhance the competitiveness of investigators to conduct research and obtain additional funding for clinical and translational research addressing highly prevalent diseases and those that affect the medically underserved in Puerto Rico. The long-term goal of the Alliance is to transform clinical and translational research in Hispanic populations in the Mainland and in Puerto Rico by promoting inter-disciplinary collaboration and leverage of resources to address diseases affecting Hispanic communities. Successful implementation of the Alliance will advance our fundamental knowledge of Hispanic health in this ethnic subgroup, which is increasingly represented in the U.S. mainland population. The Alliance is innovative because it will: (1) create a Hispanic-centered research hub integrating resources to support researchers in PR and national partners; (2) implement the Hispanic Real World clinical research data warehouse; and (3) establish a Community Health & Research Council comprised of diverse community partners emphasizing a community-centered, bi-directional research focus to impact health policy and ultimately improving health outcomes in our Hispanic community. The Alliance’s overall aims are specified below. Specific Aim 1: Enhance an island-wide infrastructure and human resource network and synergize with local and national partners to conduct clinical and translational research in Puerto Rico. Specific Aim 2: Provide professional development activities to enhance the ability of investigators to develop competitive clinical and translational research programs with an emphasis on Hispanic health needs. Specific Aim 3: Facilitate the generation and dissemination of knowledge to and from the bench and the community to improve health outcomes that affect Hispanic communities in Puerto Rico and across United States. Specific Aim 4: Catalyze and sustain the integration of trans/multi/inter-disciplinary collaborations to conduct clinical and translational research within and across institutions, organizations, community networks, and health programs in Puerto Rico and other IDeA states. The proposed  Hispanic  Alliance for  Clinical and  Translational  Research is relevant to public health because it will help advance our fundamental knowledge of  ethnic-­specific  factors that could explain the disproportionate burden of certain diseases,  and the limited or lack of effective treatment for this ethnic subgroup,  which is increasingly represented in the US mainland population. The long-­term goal of the Alliance is to transform clinical and translational research in  Hispanic populations in the  Mainland and in  Puerto  Rico by promoting  inter-­ disciplinary collaboration and leverage of resources to address diseases affecting  Hispanic communities.  The project is relevant to the  NIH  mission because it will contribute to training the next generation of scientists, develop research capacities, and will enhance the diversity of the scientific workforce.